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Total Protein in Serum (Mass Concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood serum, which includes important proteins like albumin and globulins that help maintain fluid balance, support immunity, and transport nutrients.

Quick summary

["Your blood protein levels can signal health issues like malnutrition, kidney disease, or liver problems."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
39091-4
Short code
Johnson grass IgE/IgE total %
Synonyms
Johnson grass IgE/IgE total %
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why It Matters in Your Health

Blood proteins play several critical roles in your body. Albumin helps keep fluids in your blood vessels, preventing swelling, and supports the transport of fats and hormones. Globulins, which include antibodies, assist in fighting infections and inflammation. Abnormal levels can indicate conditions like dehydration, liver disease, or chronic kidney disease.

What Can Affect Your Results?

Several factors may influence your total protein test results, including recent meals (especially high-protein foods), certain medications (like steroids or diuretics), dehydration or overhydration, and underlying health conditions like kidney disease or liver disorders.

Common Conditions Monitored

Healthcare providers often check total protein levels to diagnose or monitor conditions such as malnutrition, chronic kidney disease, liver disease (like cirrhosis), and certain autoimmune disorders. It can also help assess the effectiveness of treatments for these conditions.

What to Expect During the Test

This test is typically done by drawing a small amount of blood from a vein in your arm. The blood sample is sent to a lab, where it is processed to separate serum (the liquid part after clotting). The protein content is then measured using specialized laboratory techniques.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance of Total Protein Levels

Short name

Total Protein

Frequently asked questions

What does my total protein test result mean?
Your results will be compared to a reference range provided by your healthcare team. While reference ranges can vary slightly between labs, low levels may suggest malnutrition, kidney or liver disease, or excessive fluid loss. High levels could indicate dehydration, multiple myeloma (a blood cancer), or conditions that cause the liver to produce too much protein.
How often should I get this test?
The frequency of this test depends on your medical condition and overall health. Your healthcare provider will determine if and when to repeat it. For example, people with chronic kidney or liver disease may need regular monitoring, while others might only need it if symptoms arise or during specific medical evaluations.
Can I prepare for this test?
You can usually prepare for this test by avoiding heavy meals or alcohol 12 to 24 hours before your appointment. Staying hydrated is generally recommended unless your healthcare provider advises otherwise. If you are on certain medications, inform your healthcare provider before the test.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy