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Plasma or Serum Mass Concentration of Mutant Glycoprotein (e.g., Alpha-1 Antitrypsin Variant)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of a specific variant form of Alpha-1 Antitrypsin, a protein that helps protect your lungs and liver from damage. It’s often used to assess genetic risks for conditions like chronic obstructive pulmonary disease (COPD) or liver disease.

Quick summary

["Helps identify genetic variants linked to lung or liver health risks."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
63179-6
Short code
Johnson grass smut IgG-mCnc
Synonyms
Johnson grass smut IgG-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have a family history of Alpha-1 Antitrypsin deficiency, symptoms of lung issues (like persistent cough or shortness of breath), or liver problems. It can also be part of a genetic screening process.

What to Expect Before the Test

No special preparation is usually needed. You’ll provide a blood sample, typically drawn from your arm. If you’re taking blood thinners, let your provider know before the test.

What the Results Mean

Results show the concentration of the specific A1AT variant in your blood. Higher or lower levels may indicate an increased risk for conditions like emphysema or liver disease, depending on the variant. Your provider will discuss these findings with you.

Common Conditions Linked to This Test

Alpha-1 Antitrypsin deficiency is linked to chronic lung diseases (like emphysema) and liver diseases. Detecting the variant early can help manage symptoms and plan treatment.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test helps identify genetic mutations in Alpha-1 Antitrypsin, which can affect lung and liver health. Early detection allows for proactive monitoring and support, especially if you have a family history of related conditions.

Short name

Alpha-1 Antitrypsin (A1AT) Variant Mutation Level

Frequently asked questions

What does a high or low result mean for my health?
A high or low result depends on the specific variant and your overall health. Your provider will interpret the results in the context of your symptoms, family history, and other tests. It may not indicate a diagnosis alone but could guide further testing or monitoring.
How often should I get this test?
Your provider will determine how often you need retesting based on your risk factors, symptoms, and test results. Some people with a known variant may need monitoring every few years or more frequently if symptoms develop.
Can lifestyle changes help if I have this variant?
Yes! Quitting smoking, maintaining a healthy weight, and following a lung-healthy diet can help manage symptoms. Your provider may also recommend lung function tests or other treatments tailored to your specific variant.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy