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Serum or plasma concentration of dehydroepiandrosterone sulfate (DHEA-S)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of dehydroepiandrosterone sulfate (DHEA-S), a hormone produced by the adrenal glands that plays a role in energy levels, stress response, and sex hormone production.

Quick summary

["DHEA-S helps assess adrenal gland function and overall hormone balance."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
9880-6
Short code
J Pnt Depr L-I
Synonyms
J Pnt Depr L-I
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ekg
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order a DHEA-S test to evaluate adrenal gland health, especially if you have symptoms like fatigue, low energy, or hormonal imbalances. It can also be used in conditions such as adrenal insufficiency, Cushing’s syndrome, or to monitor treatment for hormone-related disorders.

What Does the Test Involve?

A blood sample is taken from a vein in your arm. The blood is sent to a lab for analysis to measure the levels of DHEA-S in your serum or plasma.

What Do Results Mean?

Results are not typically provided with specific reference ranges in a general setting. Instead, they are interpreted in the context of your overall health, symptoms, and medical history. Your doctor will discuss any abnormal findings with you.

Common Reasons for Testing

DHEA-S testing is often done to diagnose or monitor conditions like adrenal disorders, hormonal imbalances, or to check adrenal function in people with chronic illnesses.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

DHEA-S

Frequently asked questions

What preparation is needed before the test?
No special preparation is usually required, but you may be asked to fast for 8–12 hours before the blood draw if instructed by your healthcare provider. Avoid caffeine or alcohol for a few hours before testing.
How long does it take to get results?
Results are typically available within a few days to a couple of weeks, depending on your lab’s processing time and your healthcare provider’s workflow.
Can lifestyle changes affect DHEA-S levels?
Yes, lifestyle factors such as stress, diet, exercise, and sleep can influence hormone levels, including DHEA-S. Reducing stress, maintaining a balanced diet, and getting adequate rest may support healthy hormone function.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy