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Serum or plasma concentration of total protein

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood, which includes albumin and other proteins like globulins. Proteins help maintain fluid balance, support immunity, and transport nutrients.

Quick summary

["Total protein levels can indicate hydration status, liver function, or underlying health conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
9886-3
Short code
J Pnt Depr L-V4
Synonyms
J Pnt Depr L-V4
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ekg
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test to check for conditions like dehydration, kidney disease, liver problems, or malnutrition. It can also help monitor protein-losing disorders or assess overall health in certain situations.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the test if it’s part of a more complex evaluation. Bring any medications you’re taking to your appointment.

How the Test Works

A blood sample is drawn from a vein, typically in your arm. The sample is sent to a lab where it’s analyzed to determine the total protein concentration in your serum or plasma.

What the Results Mean

Results are reported in grams per deciliter (g/dL). Low levels may suggest dehydration, kidney or liver disease, or poor nutrition. High levels could indicate conditions like multiple myeloma or severe dehydration.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein

Frequently asked questions

What causes low total protein levels?
Low total protein levels can result from conditions like kidney disease, liver problems, malnutrition, or severe dehydration. Chronic illnesses, such as inflammatory diseases or certain cancers, may also affect protein production or retention in the body.
What causes high total protein levels?
High total protein levels may be due to dehydration, multiple myeloma (a blood cancer), or severe inflammation. Rarely, it can occur in conditions affecting the kidneys or liver, though these are less common causes of elevated protein.
How often should I get this test?
The frequency depends on your health status and why the test was ordered. Your doctor will determine how often to repeat it, whether it’s part of routine check-ups or monitoring a specific condition.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy