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Serum or plasma concentration of total protein by nephelometry

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of protein in your blood, which helps assess overall protein levels and kidney function.

Quick summary

["Total protein levels can signal kidney health or other health concerns."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
9887-1
Short code
J Pnt Depr L-V5
Synonyms
J Pnt Depr L-V5
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ekg
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to check for conditions like kidney disease, liver problems, malnutrition, or dehydration. It can also help monitor protein loss due to conditions like nephrotic syndrome or certain infections.

What to Expect Before the Test

No special preparation is usually needed. You may be asked to fast for 8–12 hours before the test if it’s part of a liver or kidney function panel. Bring any medications you’re taking.

What Happens During the Test?

A blood sample is drawn from a vein in your arm. The blood is sent to a lab where it’s analyzed to measure total protein levels.

What the Results Mean

Results are compared to a general reference range, but your specific range may vary based on age, sex, and health status. Low levels may indicate malnutrition or kidney issues, while high levels could signal liver disease or dehydration.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein

Frequently asked questions

What causes low total protein levels?
Low total protein levels can result from poor nutrition, kidney disease, liver problems, or conditions that cause excessive protein loss (e.g., severe infections, burns). Chronic kidney disease or certain medications may also contribute.
What causes high total protein levels?
High total protein levels may occur due to dehydration, liver disease, multiple myeloma, or certain inflammatory conditions. Rarely, it can be genetic or linked to conditions like nephrotic syndrome.
How often should I get this test?
Frequency depends on your health status. Your doctor may recommend this test annually for chronic conditions like kidney disease or liver disorders, or as part of routine check-ups if you have risk factors.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy