Skip to content

Serum or Plasma Substance Concentration (General Protein Electrophoresis Profile)

Published: August 9, 2026Updated: August 16, 2026

This test measures the distribution of different proteins in your blood, often used to identify abnormalities in protein levels that may suggest conditions like infections, liver disease, or certain cancers.

Quick summary

["Helps diagnose and monitor conditions affecting protein balance in your blood."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
18545-4
Short code
J Pnt ST Amp+20ms L-AVL
Synonyms
J Pnt ST Amp+20ms L-AVL
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ekg
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

Electrophoresis separates blood proteins based on size and charge, allowing for the detection of abnormal protein patterns. This includes proteins like albumin, globulins, and other fractions that may appear elevated or reduced in certain diseases.

Common Conditions Evaluated

Protein electrophoresis is commonly used to screen for conditions such as multiple myeloma (a cancer of plasma cells), Waldenström macroglobulinemia (a type of lymphoma), liver disease, kidney disease, and certain autoimmune disorders.

Sample Collection and Preparation

Blood is drawn from a vein, typically in the arm. The sample is then processed to separate serum or plasma, which is sent to the lab for electrophoresis analysis.

Interpreting Results

Results show the relative amounts of different protein bands. Abnormal patterns may indicate specific protein abnormalities that require further medical evaluation.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Protein Electrophoresis Profile

Frequently asked questions

Why might my doctor order this test?
Your doctor may recommend this test to investigate unexplained symptoms like fatigue, weight loss, swelling, or to monitor known conditions affecting protein levels in your blood.
What are the typical reference ranges?
Reference ranges vary by lab and protein fraction. Your results will be compared to your specific lab’s standards, and your doctor will interpret them in the context of your overall health.
How long does it take to get results?
Results are usually available within 24 to 48 hours, depending on lab processing times.
  1. 1
  2. 2
  3. 3

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy