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Quantitative measurement of total protein concentration in serum or plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of protein in your blood, which helps your body function properly. Proteins are essential for building and repairing tissues, transporting nutrients, and maintaining fluid balance.

Quick summary

["Your blood protein levels can indicate overall health, hydration, or potential medical conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
18546-2
Short code
J Pnt ST Amp+20ms L-AVR
Synonyms
J Pnt ST Amp+20ms L-AVR
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ekg
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Doctors may order a total protein test to check for conditions like dehydration, kidney disease, liver problems, or certain types of infections. It can also help monitor long-term health in people with chronic illnesses.

What to Expect Before the Test

No special preparation is needed for this test. You may have a small needle inserted into a vein in your arm to draw blood. If you’re on blood thinners or have a history of bleeding, let your doctor know.

What Happens During the Test?

A healthcare professional will clean the area, insert a needle, and collect a small sample of blood. The process usually takes a few minutes. You may feel a slight pinch, but it’s generally quick and painless.

What Are the Possible Results?

Results are compared to a general reference range, but your actual values may vary based on age, health, and other factors. Low or high protein levels can signal underlying health concerns that need further evaluation.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein

Frequently asked questions

What causes low protein levels in blood?
Low protein levels can result from conditions like kidney disease (where proteins are lost in urine), liver disease (where proteins aren’t made properly), malnutrition, or certain infections. It may also occur due to excessive protein loss from wounds or burns.
What are the common symptoms of abnormal protein levels?
Symptoms may include swelling (edema), fatigue, weight loss, frequent infections, or changes in skin appearance. However, some people may not show symptoms until protein levels are severely low or high. Your doctor will interpret results in the context of your overall health.
Can diet affect total protein test results?
Dietary changes can influence protein levels, but a single blood test doesn’t reflect long-term dietary habits. If your doctor suspects diet-related changes, they may recommend follow-up tests or dietary adjustments. Avoiding extreme protein-rich meals before testing isn’t typically advised unless specified.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy