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Serum or plasma concentration of total protein by nephelometry

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of protein in your blood, which helps your body maintain proper fluid balance, support immune function, and transport nutrients.

Quick summary

["Total protein levels can indicate hydration status, liver function, or potential protein loss (e.g., kidney disease)."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
18553-8
Short code
J Pnt ST Amp+20ms L-V4
Synonyms
J Pnt ST Amp+20ms L-V4
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ekg
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like swelling, unexplained weight changes, fatigue, or if they suspect conditions like kidney disease, liver problems, or malnutrition. It’s also used to monitor chronic conditions like kidney disease or heart failure.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for 8–12 hours if your test involves a blood draw for other purposes. Wear comfortable clothing and plan to stay for about 15 minutes while blood is drawn.

What Happens During the Test

A healthcare professional will insert a small needle into a vein in your arm. You may feel a brief pinch, but the procedure is quick. The blood sample is then sent to the lab for analysis.

What the Results Mean

Your results will show the total protein concentration in your blood. While reference ranges vary by lab, low levels may suggest conditions like kidney disease or malnutrition, while high levels could indicate dehydration, liver disease, or inflammation.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Total Protein

Frequently asked questions

What does my total protein level indicate?
Low total protein levels may signal conditions like protein-losing disorders (e.g., kidney or gastrointestinal issues), liver disease, or severe malnutrition. High levels could indicate dehydration, chronic inflammation, or certain liver or kidney conditions. Always discuss your results with your provider for personalized interpretation.
How often should I get this test?
Your provider will determine how often you need this test based on your health status, symptoms, and medical history. Some people get it annually or more frequently if they have chronic conditions like kidney disease or liver problems.
Can I eat or drink before this test?
Most often, no fasting is required for this test alone. However, if your provider has ordered other blood tests, they may specify fasting requirements. Always follow your provider’s instructions.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy