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Serum or plasma concentration of total protein by nephelometry

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of protein in your blood, which helps assess overall protein levels and kidney function.

Quick summary

["Total protein levels can signal kidney issues or protein loss from other body systems."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
18554-6
Short code
J Pnt ST Amp+20ms L-V5
Synonyms
J Pnt ST Amp+20ms L-V5
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ekg
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test to check for conditions like kidney disease, malnutrition, liver problems, or certain types of cancer. It can also help monitor protein loss from conditions like nephrotic syndrome or severe burns.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into a vein (usually in your arm) to draw blood. If you’re on blood thinners, let your doctor know before the test.

What the Results Mean

Higher-than-normal levels might indicate liver disease, dehydration, or overproduction of proteins. Lower-than-normal levels could signal malnutrition, kidney problems, or excessive protein loss.

Common Conditions Monitored

This test is often used alongside others to diagnose or track conditions like chronic kidney disease, liver cirrhosis, or protein-losing gastrointestinal diseases.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical significance: Elevated total protein may reflect conditions such as multiple myeloma, severe dehydration, or chronic inflammation, while low levels often point to malnutrition, kidney dysfunction, or excessive protein loss (e.g., from burns or nephrotic syndrome).

Short name

Total Protein

Frequently asked questions

What causes abnormal protein levels?
Abnormal results can stem from medical conditions (e.g., liver/kidney disease), dietary factors (e.g., poor protein intake), or medications. Your doctor will review your full health picture to determine the cause.
How often should I get this test?
Frequency depends on your health status. Your doctor may recommend periodic checks if you have conditions like kidney disease, liver issues, or cancer. Follow-up tests are usually scheduled based on your treatment plan.
Can I eat or drink before the test?
You can eat and drink normally unless your doctor specifies otherwise. Avoid alcohol or heavy meals 2–3 hours before the blood draw to ensure accurate results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy