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Serum or plasma concentration of total protein by nephelometry

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood, which includes important proteins like albumin and globulins that help maintain fluid balance, support immunity, and transport nutrients.

Quick summary

["Total protein helps assess overall health, kidney function, and potential protein-losing conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
18564-5
Short code
J Pnt ST Amp+60ms L-V3
Synonyms
J Pnt ST Amp+60ms L-V3
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ekg
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to check for conditions like kidney disease (where protein might leak into urine), liver problems (which can affect protein production), malnutrition, or certain immune disorders. It can also help monitor long-term health in people with chronic illnesses.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for 8–12 hours before the test if it’s part of a broader panel. Bring any medications or supplements you’re taking, as they may affect results.

How the Test Works

A blood sample is drawn from a vein in your arm. The lab measures the protein concentration using nephelometry, a technique that detects light scattering from proteins in the sample.

Possible Results and Their Meaning

Low total protein levels might suggest malnutrition, liver disease, or kidney problems. High levels could indicate dehydration, multiple myeloma (a blood cancer), or severe inflammation. Your results will be compared to your individual baseline and clinical context.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein

Frequently asked questions

What questions might you have?
This test alone doesn’t diagnose a specific condition—it’s often part of a broader evaluation. If your results are abnormal, your provider may recommend further tests, like urine protein checks or liver function tests.
How do I prepare for follow-up results?
Ask your provider when to expect results and whether they’ll discuss them directly or share them with your primary care team. Follow-up may include additional bloodwork, imaging, or lifestyle recommendations based on your results.
Can diet affect this test?
Yes, high-protein diets or certain medical conditions (like kidney disease) can influence results. If you’re on a special diet, let your provider know to avoid confusion in interpretation.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy