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Valproate (Serum or Plasma) Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of valproate, a medication used to control seizures or mood disorders, in your blood.

Quick summary

["Valproate levels help ensure you’re taking the right dose for your condition."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
73923-5
Short code
JWH-018 pentanoate Bld Ql
Synonyms
JWH-018 pentanoate Bld Ql
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test to check if your valproate levels are within the safe range. It helps prevent side effects like dizziness, nausea, or liver problems that can happen if levels are too high. It’s also used to monitor long-term treatment for conditions like epilepsy or bipolar disorder.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into your arm or vein to draw blood. If you’re on valproate, your doctor will likely schedule this test regularly to track your levels.

What the Results Mean

Results are compared to a general reference range, but your doctor will interpret them based on your specific needs, dose, and health status. Too-low or too-high levels can affect how well your medication works or cause side effects.

Common Side Effects to Watch For

While valproate is generally safe when monitored, high levels can cause drowsiness, stomach upset, or rare but serious issues like liver damage. If you experience unusual fatigue, vomiting, or skin rashes, contact your doctor right away.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Valproic Acid Level

Frequently asked questions

How often should I get this test?
Your doctor will determine the timing based on your medication schedule and condition. For example, if you take valproate daily, they may check levels every few months or as needed to adjust your dose.
Can diet or other medications affect this test?
Dietary changes or other medications (especially those metabolized in the liver) can influence valproate levels. Always tell your doctor about all medications, supplements, or recent dietary changes.
What if my levels are too high or too low?
If levels are outside the target range, your doctor may adjust your dose, switch medications, or investigate other causes like liver issues or drug interactions.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy