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Carboxylated Vitamin K-Dependent Anticoagulant Factors (Serum) – Total

Published: August 9, 2026Updated: August 16, 2026

This blood test measures levels of vitamin K-dependent coagulation factors that have been chemically modified (carboxylated) to ensure proper blood clotting function. These factors are essential for preventing excessive bleeding.

Quick summary

["Assesses vitamin K-dependent clotting protein function through carboxylation status."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
73929-2
Short code
JWH-250 5-carboxypentyl Bld Ql
Synonyms
JWH-250 5-carboxypentyl Bld Ql
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have a history of bleeding disorders, liver disease, or conditions affecting vitamin K metabolism. It can also help monitor treatment for conditions like vitamin K deficiency or anticoagulant therapy.

What to Expect Before the Test

No special preparation is typically needed. You may be asked to fast for 8–12 hours before the test, but always follow your provider’s instructions. Bring any medications or supplements you’re taking, as they may affect results.

During the Test

A healthcare professional will draw blood from a vein in your arm using a small needle. You may feel a brief pinch, but the procedure usually takes less than 5 minutes. You can resume normal activities immediately afterward.

What the Results Mean

Results help determine if your body’s natural clotting proteins are functioning correctly. Abnormal levels may indicate issues with vitamin K availability, liver function, or inherited bleeding disorders. Your provider will interpret results in the context of your medical history and symptoms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Carboxylated Factors (Serum)

Frequently asked questions

What could cause abnormal results?
Low levels may suggest vitamin K deficiency, liver disease, malabsorption issues (e.g., celiac disease), or certain medications (e.g., antibiotics). High levels could indicate overactive vitamin K metabolism or rare genetic conditions. Always discuss results with your provider.
How often should this test be repeated?
Frequency depends on your condition and treatment plan. If you’re on long-term anticoagulant therapy (e.g., warfarin), your provider may order this test periodically to monitor clotting function. Follow their guidance for follow-up testing.
Does this test interact with other medications?
Yes, certain medications (e.g., blood thinners, antibiotics, or antacids) can affect vitamin K levels or clotting. Always inform your provider about all medications, supplements, or herbal products you take before testing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy