Alpha-1 Antitrypsin (A1AT) Serum Concentration
This test measures the level of Alpha-1 Antitrypsin, a protein produced by the liver that helps protect the lungs and other organs from damage caused by enzymes released during inflammation.
["Alpha-1 Antitrypsin levels can help diagnose or monitor conditions affecting your lungs or liver."]
Key facts at a glance
- LOINC
- 10496-8
- Short code
- Kappa LC Ag Tiss Ql ImStn
- Synonyms
- Kappa LC Ag Tiss Ql ImStn
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- immune-stain
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Is Done
Your healthcare provider may order this test if you have symptoms of lung diseases like chronic obstructive pulmonary disease (COPD) or emphysema, or if you have a family history of Alpha-1 Antitrypsin deficiency. It may also be used to check liver function or diagnose conditions such as cirrhosis or hepatitis. Sometimes, it is part of a screening for genetic disorders that affect protein production.
What to Expect Before the Test
No special preparation is usually needed for this blood test. You may be asked to fast for 8 to 12 hours before the test if it is part of a liver function panel, but this is not always required. Bring any medications or supplements you are currently taking to your appointment.
What Happens During the Test
A healthcare professional will draw blood from a vein in your arm using a small needle. You may feel a slight sting, but it usually doesn’t cause significant discomfort. The blood will be collected in a tube and sent to the lab for analysis.
What the Results Mean
Low levels of Alpha-1 Antitrypsin can indicate a genetic deficiency that may lead to lung diseases or liver problems. High levels might be seen in certain liver diseases or during pregnancy. Your healthcare provider will interpret the results in the context of your medical history and symptoms to determine the next steps.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Alpha-1 Antitrypsin deficiency is a genetic condition that can cause lung diseases such as emphysema and liver diseases like cirrhosis. Low levels of this protein can accelerate the breakdown of lung tissue and damage liver cells. Regular monitoring of Alpha-1 Antitrypsin levels is crucial for managing these conditions and planning appropriate treatments.
Short name
Alpha-1 Antitrypsin
Frequently asked questions
What causes low Alpha-1 Antitrypsin levels?
How is Alpha-1 Antitrypsin deficiency diagnosed?
Can Alpha-1 Antitrypsin levels be increased through diet or supplements?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy