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Albumin in Cerebrospinal Fluid (CSF) by Electrophoresis

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of albumin protein in your cerebrospinal fluid (the fluid surrounding your brain and spinal cord). It helps assess conditions affecting the blood-brain barrier or the fluid itself.

Quick summary

["Albumin in CSF can indicate issues like blood leakage into the brain or inflammation."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
48777-7
Short code
Kappa LC Free/Alb Ser+CSF
Synonyms
Kappa LC Free/Alb Ser+CSF
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if you have symptoms like headaches, vision changes, or neurological problems that could suggest conditions like meningitis, brain tumors, or bleeding disorders. It can also help diagnose or monitor certain autoimmune diseases or infections.

What to Expect Before the Test

You’ll have a small needle inserted into your arm or back to draw a sample of CSF. This is usually done in a hospital or clinic setting under sterile conditions. You may feel a brief pinch, but the procedure is quick and painless.

How the Test Works

The CSF sample is analyzed using electrophoresis, a method that separates proteins based on size and charge. Albumin is one of the proteins detected in this process.

What the Results Mean

High levels of albumin in CSF may suggest blood has leaked into the brain (e.g., due to trauma, bleeding, or certain infections). Low or normal levels may indicate healthy fluid composition or conditions like multiple sclerosis.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

CSF Albumin Profile

Frequently asked questions

How often will I need this test?
The frequency depends on your symptoms and diagnosis. Your doctor will determine if repeat testing is needed for monitoring or follow-up.
What are the possible risks or side effects?
The most common side effect is a mild bruise or soreness at the injection site. Rarely, there may be mild headaches or dizziness, but these are usually temporary.
Can I drink or eat before the test?
No special preparation is needed, but follow your doctor’s instructions regarding fluids or medications if you have any specific instructions.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy