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Complement Factor H (CFH) Quantitative, Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of Complement Factor H in your serum. It helps assess how well your immune system’s complement system is functioning, particularly in conditions affecting the blood-brain barrier or immune regulation.

Quick summary

["This test may be used to evaluate inherited or acquired disorders linked to CFH levels."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
111247-3
Short code
Kappa LC Free Msmt Ur
Synonyms
Kappa LC Free Msmt Ur
Category
chemistry
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms or a history of conditions like age-related macular degeneration (AMD), atypical hemolytic uremic syndrome (aHUS), or other immune-related disorders. It may also be part of a broader evaluation for unexplained bleeding, kidney issues, or autoimmune diseases.

What to Expect Before the Test

No special preparation is typically needed. You may be asked to fast for 8–12 hours before the test if your provider specifies it, but this is not always required. Bring a list of medications you’re taking, as some may affect results.

What Happens During the Test

A healthcare professional will draw blood from a vein in your arm. The blood sample is then sent to a lab for analysis using a specialized immunoassay method to measure CFH levels.

What the Results Mean

Results are compared to a reference range specific to your age, sex, and health status. Abnormally high or low levels may indicate underlying conditions that need further medical evaluation.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

CFH Serum Level

Frequently asked questions

What causes abnormal CFH levels?
Abnormal CFH levels can result from genetic mutations (e.g., in inherited disorders), chronic inflammation, autoimmune diseases, or certain medications. Rarely, it may also be influenced by liver disease or kidney dysfunction.
How long does it take to get results?
Results are usually available within 1–3 business days, depending on lab processing times. Your provider will discuss the findings with you during a follow-up visit.
Can diet or medications affect this test?
Some medications (e.g., steroids, immunosuppressants) may influence immune-related proteins like CFH. Avoiding alcohol and certain supplements (e.g., omega-3s) for 24 hours before testing can help ensure accurate results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy