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Serum Alpha-1 Antitrypsin (A1AT) Concentration (24-Hour Profile)

Published: August 9, 2026Updated: August 16, 2026

This test measures your levels of Alpha-1 Antitrypsin, a protein produced by the liver that helps protect the lungs from damage caused by enzymes released during inflammation or infection.

Quick summary

["A1AT levels help assess lung health and identify potential genetic deficiencies."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
49908-7
Short code
Kappa LC/Lambda 24h Ur
Synonyms
Kappa LC/Lambda 24h Ur
Category
chemistry
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms like chronic cough, shortness of breath, or lung diseases such as emphysema or chronic obstructive pulmonary disease (COPD). It may also be recommended if you have a family history of A1AT deficiency, which can lead to lung or liver problems over time.

What to Expect Before the Test

No special preparation is needed for this test. You may have a blood sample drawn from a vein in your arm. If you are on blood thinners, let your provider know before the test.

What the Test Results Mean

Results are used to determine if your A1AT levels are low or high. Low levels may indicate a genetic deficiency that increases lung or liver disease risk. High levels may be seen in certain liver conditions or during pregnancy.

Common Conditions Linked to A1AT Levels

Low A1AT levels are strongly linked to conditions like Alpha-1 Antitrypsin Deficiency (A1ATD), which can cause lung diseases like emphysema or chronic bronchitis. It may also affect the liver.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

A1AT Profile

Frequently asked questions

What causes abnormal A1AT levels?
Abnormal A1AT levels can be caused by genetic mutations (hereditary deficiency), liver diseases, chronic lung conditions, or certain medications. If you have a family history of A1AT deficiency, your risk is higher.
Diagnosis typically involves blood tests to measure A1AT levels and genetic testing to confirm the specific mutation. Lungs and liver function tests may also be performed to assess potential complications.
While there is no cure for A1AT deficiency, treatments like enzyme replacement therapy (in some cases) and lifestyle changes (such as smoking cessation) can help manage symptoms and slow disease progression.
Is this test covered by insurance?
Coverage depends on your diagnosis and healthcare provider. If your doctor orders this test for a confirmed or suspected condition like A1AT deficiency, insurance may cover it. Always confirm with your insurance provider before the test.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy