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Cerebrospinal Fluid (CSF) Protein Electrophoresis (Bromocresol Green)

Published: August 9, 2026Updated: August 16, 2026

This test measures the different protein components in your cerebrospinal fluid (the fluid surrounding your brain and spinal cord) using a technique called electrophoresis with bromocresol green dye. It helps identify abnormal protein patterns that may indicate conditions affecting your nervous system.

Quick summary

["This test helps diagnose and monitor conditions like multiple sclerosis, infections, or tumors in the central nervous system."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
48773-6
Short code
Kappa LC/Lambda CSF
Synonyms
Kappa LC/Lambda CSF
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

What This Test Measures

Electrophoresis separates proteins in your CSF based on their size and electrical charge. Bromocresol green dye binds to specific protein groups, allowing for detailed analysis of protein bands. This helps identify abnormal protein distributions, such as elevated immunoglobulin levels or unusual protein patterns.

Why It’s Done

Your healthcare provider may order this test if you have symptoms like headaches, vision changes, numbness, or neurological issues. It’s also used to monitor conditions like multiple sclerosis, meningitis, or brain tumors.

Preparation

No special preparation is needed. A small amount of CSF is collected through a procedure called lumbar puncture (spinal tap) during a doctor’s visit.

What to Expect

The procedure involves inserting a needle into your lower back to collect CSF. You may feel pressure or mild discomfort, but it usually doesn’t cause pain. The test results are analyzed to check for abnormal protein patterns.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

CSF Protein Electrophoresis

Frequently asked questions

What Might This Test Show?
Abnormal protein bands or elevated levels of specific proteins (like immunoglobulins) may indicate conditions such as multiple sclerosis, Guillain-Barré syndrome, infections, or tumors. Low protein levels could suggest inflammation or other neurological disorders.
How Long Will Results Take?
Results are typically available within a few days to a week, depending on lab processing and follow-up needs.
Do I Need to Avoid Certain Foods Before the Test?
No special diet is required, but inform your doctor about any medications or supplements you’re taking, as they may affect results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy