Keratin antibody screening test (serum/plasma)

What This Test Measures

The test detects the presence of antibodies that target keratin, a protein commonly found in hair, nails, and epithelial cells. These antibodies may indicate an immune response to these proteins, which can be associated with conditions like autoimmune diseases or certain inflammatory responses.

Why It Might Be Ordered

Your healthcare provider may order this test if you have symptoms or conditions linked to keratin-related autoimmune reactions, such as nail changes, hair loss, or unexplained skin rashes. It can also be part of a broader evaluation for autoimmune disorders.

Common Uses and Indications

This screening test is typically used as part of an initial evaluation for suspected autoimmune conditions affecting keratin-containing tissues. It may be recommended if you experience persistent nail or hair abnormalities, unexplained skin lesions, or symptoms of systemic inflammation.

Sample Collection and Preparation

A blood sample is collected from a vein in your arm. The sample is processed to separate serum or plasma, which is then analyzed for the presence of keratin antibodies. No special preparation is needed, but fasting may be advised depending on your healthcare provider’s instructions.