Urine Ketones (Qualitative, 24-Hour Collection)
This test checks for the presence of ketones in your urine over a 24-hour period, which can indicate your body is breaking down fat for energy instead of glucose.
["Ketones in urine may signal metabolic stress, such as uncontrolled diabetes or fasting."]
Key facts at a glance
- LOINC
- 27065-2
- Short code
- Ketones 2h p chal Ur Ql
- Synonyms
- Ketones 2h p chal Ur Ql
- Category
- chemistry
- Sample
- urine
- Container
- Sterile urine container
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 10 mL
- Stability
- Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
This test is done to give your doctor important information about your health. It can help find a health problem early, show how well part of your body is working, or check how well a treatment is going. Knowing these details helps your care team choose the safest and most effective plan for you.
Your healthcare provider may order this test to monitor conditions like diabetes, starvation, or metabolic disorders where fat breakdown (ketosis) occurs. It helps assess whether your body is efficiently using energy sources or if additional support is needed.
Before the test, your care team will give you clear instructions on how to prepare. You may be asked to avoid eating or drinking for a certain amount of time, or to pause some medicines. Wear comfortable, loose clothing, bring a list of your current medications, and arrive a little early so you have time to check in and ask any questions.
You’ll collect all urine produced in a 24-hour period in a sterile container. Drink plenty of fluids to ensure adequate urine output. Avoid certain medications or supplements that might interfere with results.
During the test, a trained member of your care team will walk you through each step and answer your questions along the way. The test is designed to be safe, and most people tolerate it well. It usually takes only a short time, and you can normally go home the same day unless your doctor tells you otherwise.
The collected urine sample is tested for the presence of ketones using a chemical reaction that detects their concentration. Results are reported as either positive (ketones present) or negative (no ketones detected).
Your results will help your doctor better understand your health. Results within the normal range may mean everything looks as expected, while results outside that range can point to a condition that needs a closer look. Your doctor will contact you to explain what your results mean and discuss any next steps in your care.
Positive results suggest elevated ketone levels, which may indicate conditions like diabetic ketoacidosis, starvation, or prolonged fasting. Negative results mean no significant ketones were detected in your urine.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance: Ketones in Urine Can Signal Underlying Health Concerns
Short name
Urine Ketones (24h)
Frequently asked questions
Ketones in urine are typically a sign of metabolic stress. In diabetes, high blood sugar can lead to fat breakdown, producing ketones that may cause dangerous acidity in the blood (ketoacidosis). In non-diabetic cases, prolonged fasting or excessive exercise can also trigger ketones.
Your doctor may recommend this test if you have symptoms like excessive thirst, frequent urination, nausea, or unexplained weight loss, especially if you have diabetes or a history of metabolic issues.
A positive result means ketones were found in your urine. This could indicate your body is breaking down fat for energy, which may require medical attention depending on your health status and symptoms.
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy