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Serum or plasma mass concentration of immunoglobulin G (IgG) fragments or related proteins (e.g., free light chains or specific subclasses)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of certain IgG-related proteins in your blood, which may help identify conditions affecting antibody production or immune system function.

Quick summary

["Assists in diagnosing immune disorders or monitoring protein-related conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
73747-8
Short code
KLH IgM Ser-mCnc
Synonyms
KLH IgM Ser-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
1.5
Ref high
9
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
83002
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

IgG is a key part of your immune system, but this test focuses on specific fragments or subclasses of IgG or related proteins, such as free light chains. These can be elevated in conditions like multiple myeloma, certain autoimmune diseases, or after immune system stimulation.

Why It Might Be Ordered

Your healthcare provider may order this test if you have symptoms like frequent infections, unexplained fatigue, or signs of immune dysfunction. It could also be used to monitor treatment responses in conditions affecting protein levels in the blood.

Common Conditions Affecting Results

High levels may suggest conditions like multiple myeloma, certain lymphomas, or severe infections. Low levels could indicate immune deficiencies or chronic diseases that deplete proteins. The test may also be used in research or specialized diagnostics.

Sample Collection and Preparation

A blood sample is drawn from a vein, typically in your arm. The blood is processed to separate serum or plasma, which is then analyzed for the specific protein fragments or concentrations.

Reference range

Follicular: 1.5-9.0 mIU/mLN/A

Specimen: serum

For females: inform if menstrual cycle status. For certain tests, timing within menstrual cycle may matter.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

IgG-related protein mass concentration

Frequently asked questions

How long does it take to get results from this test?
Results are usually available within 1 to 3 business days, depending on lab processing and any additional confirmatory testing required.
What does a high or low result mean?
High results may indicate conditions like multiple myeloma or immune system overactivity, while low results could point to immune deficiencies or chronic illnesses affecting protein metabolism. Always discuss results with your healthcare provider.
Can diet or medications affect this test?
Certain medications (e.g., steroids, chemotherapy) or dietary supplements may influence protein levels. Inform your healthcare provider about all medications and supplements you take before testing.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy