Cerebrospinal Fluid Protein Electrophoresis (Qualitative)

Why This Test Is Done

Your doctor may order this test if they suspect conditions such as multiple sclerosis, Guillain-Barré syndrome, infections like meningitis or encephalitis, or other neurological diseases that alter protein levels in CSF. It’s often done after a lumbar puncture (spinal tap) to collect CSF for analysis.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for a few hours before the procedure if you’re having a lumbar puncture. Inform your doctor about any medications you’re taking, as some may affect results.

During the Test

A small amount of CSF is collected through a needle inserted into your lower back. The fluid is then sent to the lab for electrophoresis, a process that separates proteins based on size and charge. The results are qualitative, meaning they identify patterns rather than specific protein amounts.

What the Results Mean

Results show the distribution of proteins in CSF, such as albumin, globulins, and other proteins. Abnormal patterns (e.g., high levels of immunoglobulin G or specific globulins) may indicate inflammation, infection, or demyelinating diseases. Your doctor will interpret results in the context of your symptoms and medical history.