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C-reactive protein (CRP) with high-sensitivity measurement

Published: August 9, 2026Updated: August 16, 2026

This blood test measures a protein called C-reactive protein, which your body produces in response to inflammation. It’s often used to check for signs of inflammation that may not be obvious otherwise.

Quick summary

["hs-CRP helps identify inflammation, which can be linked to conditions like heart disease or autoimmune disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
14355-2
Short code
KOH Prep Cvx
Synonyms
KOH Prep Cvx
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
koh-preparation
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why hs-CRP Matters in Your Health

High levels of CRP can signal inflammation in your body, even if you don’t have symptoms. This test is particularly useful for monitoring conditions where inflammation plays a role, such as cardiovascular risks or certain infections.

How the Test Works

Your blood sample is taken and analyzed using a sensitive method to detect CRP levels. The test measures the protein’s concentration in the blood, which can help doctors assess inflammation levels accurately.

Common Uses for hs-CRP Testing

Doctors may order this test to evaluate risk for heart disease, track inflammation in autoimmune diseases, or monitor responses to treatments that target inflammation.

What to Expect Before the Test

No special preparation is needed, but you may want to avoid strenuous exercise or heavy meals 24 hours before the test to get more accurate results.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

hs-CRP

Frequently asked questions

What does a high hs-CRP level mean?
A high CRP level suggests inflammation is present in your body. While it doesn’t always indicate a specific condition, it can signal areas where your immune system is overactive, which may increase risks for chronic diseases like heart disease or certain cancers.
Can low CRP levels be dangerous?
Low CRP levels typically mean your body is not experiencing significant inflammation. However, very low levels might raise questions about immune function, especially in people with known inflammatory conditions or those undergoing treatment for it.
How often should I get this test?
Your doctor will determine the frequency based on your health status, medical history, and specific concerns. Regular monitoring may be recommended if you have conditions like heart disease, arthritis, or other chronic inflammatory diseases.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy