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Prostate-Specific Antigen (PSA) with Free PSA Ratio and Total PSA Measurement

Published: August 9, 2026Updated: August 16, 2026

This test measures levels of prostate-specific antigen (PSA) in your blood, including both free PSA and total PSA, to help assess prostate health.

Quick summary

["PSA testing helps detect potential prostate issues, including benign enlargement or cancer."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
70019-5
Short code
K oxytoca DNA Bld Ql NAA+probe
Synonyms
K oxytoca DNA Bld Ql NAA+probe
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What PSA Testing Measures

Your blood sample is analyzed to determine two key components: total PSA (a protein produced by the prostate) and free PSA (the portion of PSA that isn’t bound to other substances). These measurements are used to calculate a ratio that can help evaluate prostate health.

Why This Test Might Be Ordered

Doctors may order this test to monitor symptoms of prostate issues, screen for prostate cancer, or evaluate changes in prostate health over time. It’s often used alongside other tests or imaging.

Sample Collection and Preparation

A simple blood draw is used to collect your sample. No special preparation is needed, but fasting may be advised depending on your doctor’s instructions.

Test Results Interpretation

Results are interpreted based on your age, symptoms, and overall health. While PSA levels can indicate potential concerns, they are not definitive on their own. Your doctor will discuss findings with you.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

PSA Profile

Frequently asked questions

Why might my PSA test be done?
Your doctor may recommend this test to check for prostate cancer, monitor symptoms like urinary issues, or evaluate changes in prostate health, especially if you have a family history of prostate cancer or other risk factors.
What do my PSA results mean?
PSA levels alone don’t diagnose prostate cancer. They help guide further testing, such as a biopsy or additional imaging. Your doctor will review results with you in the context of your overall health and symptoms.
How often should I get this test?
Frequency depends on your age, health status, and doctor’s recommendations. Regular screenings may be advised for men at higher risk, but not everyone needs it.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy