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Respiratory Proton Transfer Rate in Exhaled Breath Condensate (Proton Transfer Rate in Breath Condensate)

Published: August 9, 2026Updated: August 16, 2026

This test measures the rate at which protons (hydrogen ions) move in the tiny droplets of moisture found in exhaled breath. It may help assess lung function and inflammation in certain respiratory conditions.

Quick summary

["This test evaluates proton transfer in exhaled breath condensate, potentially indicating lung health and inflammation."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
96324-9
Short code
K pneumo grp L resp NAA+non-prb-NCncRng
Synonyms
K pneumo grp L resp NAA+non-prb-NCncRng
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
non-probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test captures the chemical activity in exhaled breath condensate, specifically tracking how protons transfer. This reflects the chemical environment in the lungs, which can be influenced by conditions like chronic obstructive pulmonary disease (COPD) or other respiratory issues.

Why It Might Be Ordered

Your healthcare provider may order this test if you have symptoms like persistent cough, shortness of breath, or if they suspect lung inflammation or damage. It can also be used in research or specialized clinical settings to study lung function in detail.

How the Test Works

You will exhale into a special device that collects the breath condensate. The collected sample is then analyzed to measure the proton transfer rate, which is compared to expected values for your age and health status.

Preparation for the Test

No special preparation is typically needed. You may be asked to avoid certain medications or activities for a short time before the test, depending on your specific situation. Follow any instructions your healthcare provider gives you.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test can provide insights into lung inflammation, oxidative stress, and other biochemical processes in the airways. It may help diagnose or monitor conditions like COPD, cystic fibrosis, or other respiratory diseases by offering a non-invasive way to assess lung health beyond traditional spirometry.

Short name

None

Frequently asked questions

What does a high or low proton transfer rate mean?
A high proton transfer rate might suggest increased inflammation, oxidative stress, or other lung abnormalities. A low rate could indicate normal lung function or conditions where proton transfer is reduced, such as certain types of lung fibrosis. Results should always be interpreted by a healthcare professional in the context of your overall health.
How long does it take to get results?
Results are usually available within a few days to a couple of weeks, depending on the lab and your healthcare provider’s workflow. Your doctor will discuss the results with you during a follow-up visit.
Is this test painful or uncomfortable?
No, this test is completely painless. You simply exhale into a device, similar to how you might blow into a spirometer. The procedure takes only a few minutes.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy