Protein Electrophoresis (Serum/Plasma) with Bromocresol Green (BCG) Dye Shift Probe

What Does This Test Measure?

Protein electrophoresis separates blood proteins into distinct bands based on size and charge. Bromocresol green dye binds to proteins differently depending on their concentration, allowing for visual differentiation. This method helps identify patterns of protein distribution that may indicate conditions like hypoproteinemia, dysproteinemias, or kidney dysfunction.

Why Might You Need This Test?

Your healthcare provider may order this test to evaluate symptoms such as swelling, fatigue, or unexplained weight loss. It’s also used to monitor conditions like multiple myeloma, amyloidosis, or chronic kidney disease, where protein patterns in the blood can provide critical clues.

Common Uses and Conditions

This test is often used in screening for conditions that alter protein synthesis, transport, or breakdown. It may also be part of a broader evaluation for autoimmune diseases, infections, or metabolic disorders.

How Is the Test Performed?

A small blood sample is drawn from a vein, typically in your arm. The serum or plasma is then mixed with bromocresol green dye and placed in an electric field. Proteins migrate through the gel at different speeds, creating visible bands that can be analyzed.