Genomic analysis of tumor tissue for specific somatic mutations (KRAS)
This test checks for changes (mutations) in the KRAS gene that may be present in a tumor sample, often used in cancer care to guide treatment decisions.
["Helps determine if targeted therapies may be effective for your cancer treatment plan."]
Key facts at a glance
- LOINC
- 103955-1
- Short code
- KRAS Somatic mut analysis Tumor
- Synonyms
- KRAS Somatic mut analysis Tumor
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- molgen
- CPT
- 86038
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Is Done
Doctors may order this test if you have a type of cancer (such as colorectal, pancreatic, or lung cancer) where KRAS mutations are known to affect treatment options. It helps identify whether your tumor has a specific genetic alteration that could influence whether certain targeted drugs or therapies will work for you.
How the Test Works
A small sample of your tumor tissue is collected during surgery or a biopsy. The lab analyzes DNA from the sample to detect mutations in the KRAS gene, which may alter how the gene functions in cancer cells.
Sample Collection and Preparation
The test uses a tissue sample from your tumor, which is typically obtained during surgery or a procedure called a biopsy. This sample is sent to a lab where genetic testing is performed to identify mutations.
What to Expect Before the Test
You may not need to prepare for this test beyond the standard procedures for obtaining a tumor sample, such as fasting or avoiding certain medications if directed by your healthcare provider. Follow your doctor’s instructions carefully.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
KRAS mutations can influence treatment choices. For example, some cancers with KRAS mutations may not respond to certain targeted therapies, while others may benefit from specific drugs like EGFR inhibitors or other precision medicines. Results help guide personalized cancer care plans.
Short name
KRAS Mutation Test (Tumor)
Frequently asked questions
What does a positive KRAS mutation mean?
Will this test affect my treatment options?
How long does it take to get results?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy