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Genetic Mutation Analysis for KIT Proto-Oncogene (e.g., for Imatinib Resistance or Disease Monitoring)

Published: August 9, 2026Updated: August 16, 2026

This test checks for specific genetic changes in the KIT gene, which may affect how your cancer responds to treatment or help guide future care.

Quick summary

["Helps determine if a mutation may influence treatment decisions or disease progression."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
57990-4
Short code
KRIT1 gene Mut Anl Bld/T
Synonyms
KRIT1 gene Mut Anl Bld/T
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may order this test if you have a type of blood cancer (e.g., gastrointestinal stromal tumor, mastocytosis) or other conditions linked to KIT gene mutations. It could also be used to monitor treatment response or assess resistance to certain medications.

What to Expect Before the Test

You’ll typically provide a blood sample, which is sent to a lab for genetic analysis. No special preparation is needed, but discuss any medications with your provider first.

What the Results Mean

Results identify whether the KIT gene has mutations (changes) that may affect how your cancer behaves. These findings can help tailor treatment options, such as adjusting medications or exploring targeted therapies.

Common Uses of This Test

This test is often used in oncology to guide treatment decisions, especially for cancers where KIT mutations are known to play a role, such as gastrointestinal stromal tumors (GIST) or certain leukemias.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

KIT Mutation Test

Frequently asked questions

Will this test affect my insurance coverage?
Insurance coverage depends on your diagnosis, treatment plan, and local policies. Ask your healthcare provider or insurance company about coverage details before the test.
How long will it take to get my results?
Results typically take 1–4 weeks, depending on lab processing and confirmation steps. Your provider will contact you once they’re ready.
Can I eat or drink before this test?
No special diet is needed for this genetic test. However, avoid alcohol or certain medications that might interfere with results, as advised by your provider.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy