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C-reactive protein, serum/plasma concentration (high-sensitivity)

Published: August 9, 2026Updated: August 16, 2026

This test measures a protein in your blood that rises when your body is fighting inflammation or infection.

Quick summary

["hs-CRP helps doctors assess low-level inflammation that may not be obvious from other tests."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
18484-6
Short code
Ku Ab Ser Ql
Synonyms
Ku Ab Ser Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is hs-CRP Used For?

hs-CRP is often used to evaluate risk for heart disease, monitor chronic conditions like arthritis, or check for signs of inflammation after surgery or injury. It may also help guide treatment decisions for conditions like autoimmune diseases.

How Is the Test Performed?

A small blood sample is drawn from a vein, usually in your arm. The blood is sent to a lab where it is analyzed using a sensitive immunoassay method to detect the protein levels.

Why Might I Need This Test?

Your doctor may order hs-CRP if you have symptoms of inflammation, a history of heart disease, or conditions like rheumatoid arthritis. It can also be used to monitor treatment progress or check for hidden inflammation in certain situations.

What Are Common Results?

Results are typically reported in milligrams per liter (mg/L). Higher than usual levels may indicate inflammation, while lower levels suggest reduced inflammation. Exact values depend on your health status and medical history.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

hs-CRP

Frequently asked questions

What does a high hs-CRP level mean?
A high hs-CRP level suggests your body is experiencing inflammation, which could be due to infection, injury, or underlying conditions like heart disease or autoimmune disorders. Your doctor will discuss this with you and may recommend additional tests or treatments.
How often should I get this test?
The frequency depends on your medical needs. Your doctor will determine how often to check hs-CRP based on your health condition, symptoms, and treatment plan—such as every few months for monitoring or as needed for specific situations.
Can lifestyle changes affect hs-CRP levels?
Yes, lifestyle factors like diet, exercise, and managing stress can influence inflammation. Improving these habits, such as eating a heart-healthy diet, staying active, and avoiding smoking, may help lower hs-CRP levels over time.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy