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Serum Lactate Concentration (High-Performance Liquid Chromatography Method)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of lactate, a byproduct of energy production in your body, in your blood serum. It helps assess how well your body is handling oxygen and energy use.

Quick summary

["Lactate levels can indicate metabolic stress or conditions like low oxygen, heart problems, or infections."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
27955-4
Short code
Lactate 2h p chal Bld-mCnc
Synonyms
Lactate 2h p chal Bld-mCnc
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Ref low
20
Ref high
400
Critical range
— – 4 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82670
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to check for conditions like low blood oxygen (hypoxia), heart or lung problems, severe infections, or other metabolic issues. It’s often used in emergencies or during monitoring for critical illnesses.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into your arm to draw blood. If you’re on blood thinners, let your provider know before the test.

What the Results Mean

Higher-than-normal levels may suggest your body isn’t getting enough oxygen or is working too hard. Lower-than-normal levels might indicate unusual energy metabolism. Your provider will discuss these results with you based on your health history.

Common Conditions Monitored

This test is commonly used in cases of suspected shock, sepsis, heart failure, or during surgery to monitor recovery. It can also help track how well treatments for metabolic disorders are working.

Reference range

Premenopausal: 20-400 pg/mL; Postmenopausal: <30 pg/mLN/A

Specimen: whole-blood

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Elevated lactate levels often point to tissue hypoxia (low oxygen) or impaired metabolism, which can occur in conditions like heart failure, severe infections, or trauma. Low levels may be less common but could indicate rare metabolic disorders or overcorrection of acidity in the blood.

Short name

Serum Lactate

Frequently asked questions

Why might my doctor ask for this test?
Your doctor may ask for this test if you’re experiencing symptoms like dizziness, rapid breathing, confusion, or if you’re being monitored for conditions like heart problems, infections, or surgery recovery.
What does a high lactate level usually mean?
A high lactate level often means your body isn’t getting enough oxygen to certain tissues, which can happen during severe illness, low blood pressure, or during intense physical activity. Your doctor will review your symptoms and other test results to understand the cause.
Can lifestyle changes affect this test?
While diet or exercise can influence energy metabolism, this specific test measures lactate in blood serum. Your doctor will consider your overall health and other factors when interpreting results, so lifestyle changes alone won’t change the test result directly.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy