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Alpha-1 Antitrypsin (A1AT) Mass Concentration in Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of Alpha-1 Antitrypsin, a protein produced by the liver that protects lung tissue from damage caused by enzymes released during inflammation.

Quick summary

["A1AT helps prevent lung diseases and supports liver function; low levels may indicate genetic disorders or chronic conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
76614-7
Short code
LAL Fib 4-MUO substrate-cCnt
Synonyms
LAL Fib 4-MUO substrate-cCnt
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
mu-oleate-substrate
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test if you have symptoms like chronic cough, shortness of breath, or liver problems. It’s also used to screen for Alpha-1 Antitrypsin deficiency, a genetic condition linked to lung diseases like emphysema or liver cirrhosis.

What Does a Low Level Mean?

Low levels of Alpha-1 Antitrypsin can suggest a genetic deficiency, which increases your risk of lung diseases or liver issues. High levels may indicate liver disease or certain medications.

What to Expect Before the Test

No special preparation is needed, but you may fast for 8–12 hours before drawing blood. Wear a loose shirt for easy access to your arm.

What Happens During the Test?

A healthcare provider will insert a needle into your arm to draw a small amount of blood. The process usually takes a few minutes and may cause mild discomfort.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Alpha-1 Antitrypsin Deficiency

Short name

A1AT Mass

Frequently asked questions

What are the normal reference ranges?
Reference ranges vary by lab and may not be provided in plain language. Your results will be compared to your doctor’s specific guidelines.
Will I need to repeat this test?
Yes, if your levels are abnormal, your doctor may recommend follow-up tests or monitoring to track changes over time.
Does diet affect this test?
Dietary factors like smoking, alcohol, or certain medications may influence results. Your doctor will discuss any potential impacts with you.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy