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Alpha-1 Antitrypsin (A1AT) Mass Concentration in Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of Alpha-1 Antitrypsin protein in your blood. It helps assess your risk of lung disease or liver problems.

Quick summary

Alpha-1 Antitrypsin levels can indicate genetic risks for lung or liver conditions.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
76615-4
Short code
LAL Fib 4-MUP substrate-cCnt
Synonyms
LAL Fib 4-MUP substrate-cCnt
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
mu-palmitate-substrate
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if you have a family history of lung diseases like emphysema or chronic obstructive pulmonary disease (COPD), or if you have symptoms such as persistent coughing, shortness of breath, or unexplained liver issues. It can also be used to monitor treatment for conditions linked to low Alpha-1 Antitrypsin levels.

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into your arm to draw blood. It usually takes a few minutes, and you may feel a brief pinch. If you’re on blood thinners, let your doctor know before the test.

What the Results Mean

Lower than normal levels may suggest a genetic disorder that increases your risk of lung or liver disease. Higher levels might be due to certain medications or liver conditions. Your doctor will discuss results in the context of your health history.

Common Causes of Abnormal Results

Low levels are often linked to genetic mutations (e.g., PiZZ phenotype). High levels can result from liver disease, certain medications, or acute infections. Chronic liver conditions or smoking may also affect results.

Frequently asked questions

What does an abnormal result mean?
An abnormal result may indicate a genetic predisposition to lung or liver disease. Your doctor will review your symptoms, family history, and other test results to determine next steps, which could include genetic counseling or monitoring.
Can diet or lifestyle affect this test?
Dietary changes alone won’t alter Alpha-1 Antitrypsin levels, but smoking or heavy alcohol use may influence results. Your doctor may recommend avoiding these during testing if needed.
Is this test covered by insurance?
Coverage depends on your diagnosis or reason for testing. Check with your insurance provider or ask your doctor to confirm if this test is medically necessary for your situation.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy