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Lambda Free Light Chain, 24-Hour Urine, Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of free lambda light chain protein in urine collected over 24 hours. Free light chains are small antibody components released by plasma cells.

Quick summary

["The result can help evaluate and monitor conditions involving abnormal plasma-cell antibody production."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
53574-0
Short code
Lambda LC Free 24h Ur-mCnc
Synonyms
Lambda LC Free 24h Ur-mCnc
Category
chemistry
Sample
urine
Container
Sterile urine container
Units
N/A
Ref low
20
Ref high
400
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82670
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What the Test Measures

Free lambda light chains are fragments of antibodies that are not attached to a complete immunoglobulin. This urine test measures their mass concentration in a 24-hour collection.

How the Test Is Performed

Urine is collected for 24 hours, usually into a designated container. The laboratory measures the amount of lambda free light chain and may account for the total volume collected to calculate the concentration.

Why the Test Is Ordered

The test may be used as part of an evaluation for plasma-cell disorders, including multiple myeloma, or to monitor an established condition. It is often interpreted with other laboratory findings rather than alone.

Factors That May Affect the Result

Collection problems, incomplete or prolonged urine collection, changes in urine volume, and kidney function can affect the reported amount. Medication and other clinical factors may also influence interpretation.

Reference range

Premenopausal: 20-400 pg/mL; Postmenopausal: <30 pg/mLN/A

Specimen: urine

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Urine Lambda Free Light Chains

Frequently asked questions

What is a lambda free light chain?
It is a smaller fragment of an antibody released by plasma cells. It normally circulates in blood and can be found in urine.
Why is a 24-hour urine collection used?
Collecting all urine for 24 hours provides a more complete measure of how much is being excreted than a single urine sample.
Does an abnormal result confirm multiple myeloma?
No. An abnormal result may suggest a plasma-cell disorder, but it does not confirm multiple myeloma by itself and must be interpreted with other tests and clinical findings.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy