Skip to content

Cerebrospinal Fluid (CSF) Total Protein by Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein found in your cerebrospinal fluid (the fluid surrounding your brain and spinal cord). It helps assess conditions affecting the brain’s protective barrier or blood-brain barrier.

Quick summary

["Protein levels in CSF can signal inflammation, bleeding, or other neurological issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
48775-1
Short code
Lambda LC Free CSF-mCnc
Synonyms
Lambda LC Free CSF-mCnc
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Matters

Elevated protein levels in CSF may indicate conditions like meningitis, multiple sclerosis, or brain tumors. Low levels could suggest certain infections or congenital disorders. Your doctor may order this test to diagnose or monitor neurological diseases.

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into your back to collect a small sample of CSF. This is usually done in a hospital or clinic setting.

What the Results Mean

Results are compared to your doctor’s clinical picture, not absolute reference ranges. High protein levels often point to inflammation, immune responses, or structural issues in the central nervous system.

Common Conditions Monitored

This test is often used to diagnose or evaluate conditions like meningitis, Guillain-Barré syndrome, or subarachnoid hemorrhages. It may also help assess spinal cord injuries or certain autoimmune diseases.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

CSF Total Protein

Frequently asked questions

How often is this test repeated?
The frequency depends on your condition. If you have an ongoing neurological issue, your doctor may order this test periodically to monitor changes over time.
What does a normal result mean?
A normal result doesn’t guarantee no underlying issue—it means the protein concentration is within expected ranges for your body. Your doctor will consider your symptoms, medical history, and other test results before making a diagnosis.
Can diet or medications affect this test?
Diet or over-the-counter medications typically do not affect CSF protein levels. However, certain medications (like steroids) or conditions (like severe dehydration) might influence results indirectly. Always discuss any concerns with your healthcare provider.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy