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Total Protein in Serum or Plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of protein in your blood, which helps assess overall protein status and potential conditions like malnutrition or kidney disease.

Quick summary

["Your blood protein levels can signal health risks or nutritional needs."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
53748-0
Short code
LA Nt dPL PPP
Synonyms
LA Nt dPL PPP
Category
chemistry
Sample
plasma
Container
Lavender-top (EDTA) or Green-top (Heparin)
Units
N/A
Fasting
true
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Doctors may order a total protein test to check for conditions affecting protein production, such as liver disease, kidney problems, or malnutrition. It can also help diagnose or monitor certain autoimmune diseases or infections.

What Does the Result Mean?

Results may be low if you have poor nutrition, liver or kidney disease, or certain immune disorders. High levels could indicate dehydration, multiple myeloma, or inflammatory conditions. Your doctor will interpret results in the context of your overall health.

Common Conditions Monitored

This test is often used to monitor protein loss due to kidney disease, track protein synthesis in liver disorders, or evaluate nutritional status in patients who may not be eating enough protein.

Sample Collection Details

A blood sample is drawn from a vein, usually in your arm. The blood is then separated into serum (liquid part after clotting) or plasma (liquid part before clotting) for testing.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Total Protein

Frequently asked questions

What might cause abnormal results?
Low protein levels can result from conditions like cirrhosis, kidney disease, or severe malnutrition. High protein levels may suggest dehydration, chronic inflammation, or certain cancers like multiple myeloma. Always discuss results with your healthcare provider.
How often should I get this test?
The frequency depends on your health condition and doctor’s recommendations. Some patients may need it yearly or more often if managing chronic illnesses like kidney disease or liver disorders.
Can diet affect this test?
Yes, diet can influence protein levels. High-protein diets may temporarily raise results, while poor nutrition or excessive fluid intake could lower them. Your doctor may advise dietary adjustments based on your test results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy