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Immunoassay for Protein Electrophoresis (Serum/Plasma) – Qualitative or Quantitative

Published: August 9, 2026Updated: August 16, 2026

This test measures the different types of proteins in your blood, often used to check for conditions like multiple myeloma, liver disease, or kidney problems.

Quick summary

["Protein electrophoresis helps identify abnormal protein patterns that may signal underlying health concerns."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
3281-3
Short code
LA PPP-Imp
Synonyms
LA PPP-Imp
Category
chemistry
Sample
plasma
Container
Lavender-top (EDTA) or Green-top (Heparin)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is Protein Electrophoresis Used For?

Protein electrophoresis separates blood proteins into fractions (e.g., albumin, globulins) using an electric field. This helps doctors diagnose conditions affecting protein production or balance, such as infections, cancers, or metabolic disorders. Some tests may also be qualitative (yes/no) or quantitative (exact amounts).

How Is the Test Performed?

A blood sample is taken from a vein, usually in your arm. The serum or plasma is then placed in a gel and subjected to an electric current. Proteins move at different speeds, creating distinct bands that can be analyzed.

Preparation for the Test

No special preparation is needed, but you may be asked to fast for 8–12 hours before the test if it involves fasting samples (e.g., for certain protein fractions). Always follow your healthcare provider’s instructions.

What Are Common Findings?

Abnormal patterns may show high or low levels of specific proteins. For example, a spike in one fraction could indicate a disease like multiple myeloma, while altered albumin/globulin ratios may signal liver or kidney issues. Results are often interpreted by a lab specialist.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Protein Electrophoresis (Serum/Plasma)

Frequently asked questions

Why might my doctor order this test?
Your doctor may recommend protein electrophoresis if you have symptoms like unexplained weight loss, fatigue, swollen lymph nodes, or signs of organ dysfunction. It’s also used in routine blood work for certain conditions or as part of a broader diagnostic evaluation.
How long does it take to get results?
Results are typically available within 24–48 hours, depending on lab processing times. Follow-up with your healthcare provider to discuss findings and next steps.
Can I eat or drink before this test?
For standard serum/plasma electrophoresis, fasting is usually not required. However, if your test involves fasting samples (e.g., for specific protein fractions), avoid food/drinks for 8–12 hours beforehand. Always confirm with your lab or doctor.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy