Lipoprotein(a) concentration (Lp(a))

What Is Lipoprotein(a)?

Lipoprotein(a) is a unique lipoprotein particle that combines cholesterol with a protein called apolipoprotein(a). While it shares some similarities with LDL (low-density lipoprotein or 'bad' cholesterol), it behaves differently in the body and is linked to higher cardiovascular risks. High levels may contribute to plaque buildup in arteries over time.

Why Might You Need This Test?

Your healthcare provider may order this test if you have a family history of early heart disease, certain genetic conditions, or if you’ve had cardiovascular events despite typical cholesterol screening. It may also be part of a broader evaluation for atherosclerosis or peripheral artery disease.

How Is the Test Performed?

A blood sample is drawn from a vein, typically in your arm. The sample is processed to measure lipoprotein(a) concentration using a specialized immunoassay method. Results are compared to reference ranges specific to your age, sex, and health status.

What Do the Results Mean?

Results are expressed in milligrams per deciliter (mg/dL) or micrograms per milliliter (µg/mL). While there are no universal reference ranges, higher levels may indicate increased cardiovascular risk, especially when combined with other risk factors. Your provider will interpret results in the context of your overall health.