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Serum Creatinine Phosphokinase (CPK) Isoenzyme Subtype Analysis (Total CPK)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total activity of Creatine Phosphokinase (CPK), an enzyme found in heart, muscle, and brain cells. It helps assess damage to these tissues.

Quick summary

["CPK helps identify muscle or heart damage by measuring enzyme release into the blood after injury."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
35666-7
Short code
LCMV IgG+IgM Pnl Ser
Synonyms
LCMV IgG+IgM Pnl Ser
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is Creatine Phosphokinase (CPK)?

CPK is an enzyme that plays a role in energy production in cells. When tissues like the heart or muscles are damaged, CPK leaks into the bloodstream, raising its levels. This test checks the total CPK activity in your blood.

Why Might This Test Be Ordered?

Your doctor may order this test to diagnose or monitor conditions such as heart attacks, muscle injuries, or neurological disorders. Elevated CPK levels can signal recent trauma, inflammation, or disease affecting these organs.

How Is the Test Performed?

A blood sample is drawn from a vein, typically in your arm. The sample is sent to a lab where CPK activity is measured using an immunoassay or enzymatic method. Results are compared to a baseline or reference range for your health condition.

What Do Results Mean?

Results show the total CPK activity in units per liter (U/L). Higher-than-normal levels may indicate recent tissue damage, while normal levels suggest healthy tissue function. Specific CPK isoenzymes (CPK-MB for heart, CPK-MM for muscle) can further clarify findings if needed.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

CPK Total

Frequently asked questions

How often will I need this test?
This test is often ordered periodically if you have a history of heart disease, muscle disorders, or recent trauma. Your doctor will determine frequency based on your symptoms and medical history.
What are the possible side effects of the blood draw?
Most people experience mild discomfort or bruising at the needle site. Rarely, there may be slight swelling or redness. If you have a blood clotting disorder or are on blood thinners, let your doctor know before the test.
Can I eat or drink before this test?
You can eat and drink normally unless your doctor specifies otherwise. Some tests may require fasting, but this test does not.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy