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Low-Density Lipoprotein Cholesterol, Calculated, Serum/Plasma — Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

A calculated measurement of low-density lipoprotein (LDL) cholesterol, a major component of atherogenic cholesterol used to assess cardiovascular risk.

Quick summary

["Calculated LDL cholesterol helps estimate the amount of blood cholesterol associated with cardiovascular risk."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
91105-7
Short code
LDL1c SerPl-mCnc
Synonyms
LDL1c SerPl-mCnc
Category
lipid
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0
Ref high
100
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
83721
SNOMED
113079007
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

This test estimates LDL, sometimes called “bad” cholesterol, in your blood. It is usually calculated from other cholesterol measurements, including total cholesterol, HDL cholesterol, and triglycerides.

Why might I need this test?

Calculated LDL cholesterol is commonly measured during a lipid panel to help assess your risk of heart attack, stroke, and other forms of cardiovascular disease. Results may also be used to monitor cholesterol-lowering treatment or lifestyle changes.

How is the test performed?

A blood sample is collected, usually from a vein, and the laboratory uses the results of other lipid measurements to calculate the LDL concentration. The calculation may be less reliable when triglycerides are very high.

How do I prepare for the test?

Follow your clinician’s instructions, as the test may require an overnight fast. If fasting, water is generally allowed; avoid alcohol and strenuous exercise beforehand unless your clinician advises otherwise, and do not stop prescribed medicines without guidance.

Reference range

Optimal: <100 mg/dLN/A

Specimen: serum

Fasting for 12-14 hours preferred. Water is permitted. Avoid alcohol for 24 hours before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Calculated LDL cholesterol

Frequently asked questions

Is calculated LDL cholesterol the same as a direct LDL test?
No. A calculated LDL result is estimated from other measurements in the lipid panel, while a direct LDL test measures LDL in the blood sample itself.
Does LDL cholesterol have to be fasted?
It depends on your clinician’s instructions and whether other tests are being performed together. Fasting is often requested for a complete lipid panel, so follow the preparation instructions provided.
What should I do if my LDL cholesterol is high?
Your clinician can interpret the result alongside your other cholesterol levels and cardiovascular risk factors. Treatment may include dietary changes, physical activity, and, when appropriate, cholesterol-lowering medication.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy