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Low-Density Lipoprotein Cholesterol, Serum/Plasma — Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

Measures LDL (“bad”) cholesterol in blood to help assess cardiovascular risk and guide lipid-lowering treatment.

Quick summary

["Higher LDL cholesterol can increase the risk of heart disease and stroke, while lower levels generally reduce cardiovascular risk."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
49027-6
Short code
LDL7 SerPl-mCnc
Synonyms
LDL7 SerPl-mCnc
Category
lipid
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0
Ref high
100
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
83721
SNOMED
113079007
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

This blood test measures low-density lipoprotein (LDL) cholesterol, a type of fat that circulates in the bloodstream. LDL can build up in artery walls and contribute to narrowing and cardiovascular disease.

Why might I need this test?

Your clinician may order this test to assess your risk of heart attack and stroke, monitor cholesterol-lowering treatment, or evaluate metabolic conditions that can affect cholesterol levels.

How is the test performed?

A blood sample is drawn and analyzed in the laboratory. Depending on the laboratory’s testing method, the LDL result may be measured directly or calculated using results from other cholesterol tests.

How do I prepare for the test?

Follow any fasting or dietary instructions provided by your clinician. If you are unsure whether fasting is required, ask before the test, because eating can temporarily affect cholesterol measurements.

Reference range

Optimal: <100 mg/dLN/A

Specimen: serum

Fasting for 12-14 hours preferred. Water is permitted. Avoid alcohol for 24 hours before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

A high LDL cholesterol level can indicate an increased likelihood of fatty plaque buildup in the arteries, which raises the risk of heart disease and stroke. Levels are interpreted together with other cholesterol measurements, blood pressure, diabetes status, smoking history, and overall cardiovascular risk.

Short name

LDL Cholesterol

Frequently asked questions

Why is LDL cholesterol called “bad” cholesterol?
LDL transports cholesterol in the blood and can contribute to plaque buildup in artery walls. High levels are associated with greater cardiovascular risk.
Does this test require fasting?
It depends on your clinician’s instructions and the laboratory’s testing method. Fasting for a set period may be requested when results need to be interpreted alongside other lipid measurements.
Can LDL cholesterol be lowered?
Yes. Your clinician may recommend dietary changes, physical activity, weight management, or medication based on your overall cardiovascular risk and medical history.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy