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LDL Cholesterol, Calculated, Serum/Plasma — Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

A calculated blood test that estimates LDL (“bad”) cholesterol using the total cholesterol, HDL cholesterol, and triglyceride results.

Quick summary

["This test helps estimate the amount of LDL cholesterol in your blood and may be used to assess cardiovascular risk."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
43394-6
Short code
LDLc-Ac SerPl-mCnc
Synonyms
LDLc-Ac SerPl-mCnc
Category
lipid
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0
Ref high
100
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
83721
SNOMED
113079007
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

LDL cholesterol is a type of fat particle that circulates in the blood. This calculated test estimates LDL cholesterol from other cholesterol and triglyceride results. It is commonly used to help evaluate cardiovascular risk.

Why might I need this test?

Your clinician may order this test as part of a cholesterol screening or follow-up, especially if you have risk factors for heart disease, stroke, or conditions that affect cholesterol levels.

How is the test performed?

A blood sample is collected from a vein and analyzed in a laboratory. The LDL result is usually calculated from the total cholesterol, HDL cholesterol, and triglyceride values in the same sample.

How do I prepare for the test?

Follow your clinician’s instructions about fasting. Fasting for at least 9 to 12 hours may be needed for accurate results, and water is generally allowed. Tell your clinician if you are taking cholesterol-lowering medicines.

Reference range

Optimal: <100 mg/dLN/A

Specimen: serum

Fasting for 12-14 hours preferred. Water is permitted. Avoid alcohol for 24 hours before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Calculated LDL Cholesterol

Frequently asked questions

What does LDL cholesterol measure?
This test estimates the concentration of LDL, often called “bad” cholesterol, in the blood. High levels can contribute to fatty plaque buildup in arteries.
Is this the same as a direct LDL test?
Usually, no. A calculated LDL result is estimated using total cholesterol, HDL cholesterol, and triglycerides, while a direct LDL test measures LDL separately.
Do I need to fast before this test?
Fasting may be required, depending on the laboratory and the reason for testing. Follow your clinician’s instructions and ask if you are unsure whether to fast.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy