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LDL Cholesterol, Serum/Plasma — Calculated, Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

A calculated blood test that estimates the amount of LDL (“bad”) cholesterol in the blood.

Quick summary

["This test helps estimate your cardiovascular risk by measuring LDL cholesterol indirectly from other blood lipid values."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
13457-7
Short code
LDLc SerPl Calc-mCnc
Synonyms
LDLc SerPl Calc-mCnc
Category
lipid
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0
Ref high
100
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
calculated
CPT
83721
SNOMED
113079007
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

LDL cholesterol is a type of fat in the blood that can contribute to fatty buildup in arteries. This test provides a calculated estimate of LDL cholesterol rather than measuring it directly.

Why might I need this test?

Clinicians may order it as part of a cholesterol screening or follow-up, especially when assessing cardiovascular risk or monitoring treatment for high cholesterol.

How is the test performed?

A blood sample is taken from a vein and analyzed for total cholesterol, HDL cholesterol, and triglycerides. The LDL cholesterol result is then calculated from these values.

How do I prepare for the test?

Follow your clinician's instructions about fasting. A fasting sample may be requested for more accurate results, and avoiding alcohol and unusual heavy meals beforehand may also be helpful.

Reference range

Optimal: <100 mg/dLN/A

Specimen: serum

Fasting for 12-14 hours preferred. Water is permitted. Avoid alcohol for 24 hours before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Calculated LDL Cholesterol

Frequently asked questions

Is calculated LDL cholesterol the same as a direct LDL test?
No. A calculated result is estimated from total cholesterol, HDL cholesterol, and triglycerides, while a direct LDL test measures LDL in the blood without using that calculation.
Do I need to fast for this test?
Fasting requirements vary. Your clinician may request an overnight fast, especially when triglycerides are elevated or the result needs to be compared over time.
What can change my LDL cholesterol result?
Diet, weight changes, physical activity, smoking, medications, and health conditions can affect cholesterol levels. Testing at a consistent time and under similar preparation conditions can make results easier to compare.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy