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Low-Density Lipoprotein Cholesterol, Lipid Profile

Published: August 9, 2026Updated: August 16, 2026

Measures LDL (“bad”) cholesterol in the blood as part of a lipid profile, helping assess cardiovascular risk.

Quick summary

["LDL cholesterol contributes to plaque buildup in arteries, so its level is an important part of heart-risk assessment."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
105516-9
Short code
LDLFROMLIPIDPROFILE
Synonyms
—
Category
lipid
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0
Ref high
100
Fasting
true
Population
adult
Sex
all
Age range
18–65 years
CPT
83721
SNOMED
113079007
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

This test measures low-density lipoprotein (LDL) cholesterol in your blood. LDL is sometimes called “bad” cholesterol because it can contribute to fatty plaque buildup in artery walls.

Why might I need this test?

LDL cholesterol is usually checked as part of a lipid profile to help estimate your risk of heart attack, stroke, and other cardiovascular problems. Your clinician may also use it to monitor treatment intended to lower cholesterol.

How is the test performed?

A blood sample is drawn and analyzed in a laboratory. On some lipid panels, the LDL result is calculated from the measured levels of other types of cholesterol and triglycerides rather than measured directly.

How do I prepare for the test?

Follow your clinician’s instructions about fasting. Some lipid tests do not require fasting, but eating a high-fat meal beforehand can affect the results. Tell the laboratory if you are pregnant or taking a cholesterol-lowering medication.

Reference range

Optimal: <100 mg/dLN/A

Specimen: serum

Fasting for 12-14 hours preferred. Water is permitted. Avoid alcohol for 24 hours before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

A higher LDL cholesterol level can increase the risk of plaque buildup and narrowing of the arteries. Risk depends on LDL together with other factors, such as blood pressure, diabetes, smoking, family history, and overall cardiovascular risk. If your result is unexpectedly high or low, your clinician can review the complete lipid profile and the circumstances of the test.

Short name

LDL Cholesterol

Frequently asked questions

Is a higher LDL cholesterol level harmful?
Higher LDL levels generally increase cardiovascular risk over time. Your clinician will interpret the result along with your other cholesterol values and health history.
Do I need to fast before this test?
It depends on the laboratory and the other tests in your lipid panel. Fast when instructed, and avoid a high-fat meal beforehand if your clinician has given specific preparation instructions.
Can medications or supplements affect the result?
Yes. Cholesterol-lowering medicines, some other medicines, and certain supplements may affect lipid results. Do not stop prescribed treatment without discussing it with your clinician.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy