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Large Molecular Weight Lipoprotein Subclass Analysis (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures specific types of fats (lipoproteins) in your blood that carry cholesterol and triglycerides. It helps identify larger, less common lipoprotein particles that may increase your risk of heart disease.

Quick summary

["This test helps assess your cardiovascular health by detecting unusual lipoprotein patterns that may not be visible in standard cholesterol tests."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
92716-0
Short code
LDL large-b Ser-sCnc
Synonyms
LDL large-b Ser-sCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0
Ref high
100
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
83721
SNOMED
113079007
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have a family history of heart disease, high cholesterol, or other risk factors. It may also be used to monitor conditions like familial hypercholesterolemia or other lipid disorders.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for 8–12 hours before the test if your blood is drawn early in the morning. Wear comfortable clothing and arrange for someone to drive you home if you take blood thinners.

During the Test

A healthcare professional will draw blood from a vein in your arm. The process is quick and typically causes only mild discomfort. You may feel a brief pinch or sting, but the area will numb quickly.

What the Results Mean

Results show the concentration of large lipoprotein particles (e.g., chylomicrons, very-low-density lipoproteins, or abnormal variants). Elevated levels may signal an increased risk of atherosclerosis or other cardiovascular issues, but results alone don’t diagnose a condition. Your provider will interpret them in the context of your overall health.

Reference range

Optimal: <100 mg/dLN/A

Specimen: serum

Fasting for 12-14 hours preferred. Water is permitted. Avoid alcohol for 24 hours before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: How This Test Helps Healthcare Providers

Short name

Lipoprotein Screening

Frequently asked questions

What are the normal ranges for this test?
There are no standard reference ranges for this specific test because it focuses on qualitative patterns rather than absolute values. Your results will be evaluated by a healthcare provider to identify unusual lipoprotein profiles that may require further investigation.
How often should I get this test?
Your provider will determine how often you need this test based on your risk factors, medical history, and symptoms. It may be part of routine cardiovascular screening or monitoring for specific conditions.
Can I eat or drink before this test?
If fasting is required, avoid food and liquids (except water) for 8–12 hours before your blood draw. If no fasting is needed, you can eat and drink normally, but discuss this with your provider to avoid delays.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy