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Low-Density Lipoprotein Cholesterol (LDL-C) from Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of LDL cholesterol in your blood serum, a type of fat that can build up in your arteries over time.

Quick summary

["LDL cholesterol is linked to heart disease risk; lower levels are generally safer."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
96735-6
Short code
LDL med Ser-sCnc
Synonyms
LDL med Ser-sCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0
Ref high
100
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
83721
SNOMED
113079007
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

LDL cholesterol is often called the 'bad' cholesterol because high levels increase your risk of plaque buildup in your arteries, which can lead to heart attacks or strokes. Your doctor may order this test to assess your cardiovascular health, especially if you have risk factors like high blood pressure, diabetes, or a family history of heart disease.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for 8–12 hours before the test. Bring any medications you’re currently taking, as some (like statins) may affect your results. Your blood will be drawn from a vein in your arm, similar to a routine blood test.

What the Results Mean

Results help doctors determine if your LDL cholesterol is within a healthy range. While exact reference ranges vary by lab, higher levels may signal the need for lifestyle changes or medications to lower cholesterol. Your doctor will discuss these findings with you in detail.

Common Causes of Abnormal Results

High LDL cholesterol can result from poor diet (high in saturated fats), lack of physical activity, obesity, smoking, or genetic factors. Conditions like diabetes or hypothyroidism may also influence levels. Low LDL may occur if your body naturally breaks down cholesterol efficiently or if certain medications are affecting it.

Reference range

Optimal: <100 mg/dLN/A

Specimen: serum

Fasting for 12-14 hours preferred. Water is permitted. Avoid alcohol for 24 hours before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

LDL Cholesterol (Serum)

Frequently asked questions

How often should I get this test?
Typically, doctors recommend LDL cholesterol testing every 1–5 years, depending on your overall heart health. If you have risk factors, your doctor may suggest more frequent monitoring.
Can diet alone lower LDL cholesterol?
Yes! Dietary changes like reducing saturated fats, increasing fiber (from whole grains and legumes), and eating more fruits/vegetables can significantly lower LDL levels. Always follow your doctor’s personalized advice.
Do I need to avoid certain foods before the test?
No specific foods are restricted, but fasting (eating nothing but water) for 8–12 hours before testing helps provide more accurate results, as cholesterol levels can fluctuate based on meals.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy