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: Low-Density Lipoprotein Cholesterol [Mass/volume] in Serum or Plasma

Published: August 9, 2026Updated: August 16, 2026

: This blood test measures low-density lipoprotein (LDL) cholesterol, a form of cholesterol that transports it from the liver to body tissues.

Quick summary

[": Higher LDL cholesterol is associated with increased risk of plaque buildup and cardiovascular disease."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
35505-7
Short code
LDL SerPl
Synonyms
LDL SerPl
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0
Ref high
100
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
83721
SNOMED
113079007
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

: What the test measures

: The test measures the amount of LDL cholesterol in a serum or plasma sample. It may be calculated by the laboratory or measured directly, depending on the testing method used.

: Why LDL cholesterol matters

: LDL cholesterol can enter the walls of arteries, where it can contribute to fatty plaque buildup. This process, called atherosclerosis, may narrow arteries and increase the risk of heart attack or stroke.

: Factors that affect LDL cholesterol

: LDL levels can be influenced by genetics, diet, body weight, physical activity, smoking, and health conditions such as diabetes, kidney disease, and thyroid disorders. Some medicines can also affect the result.

: How the test is performed

: A blood sample is collected and analyzed in a laboratory. No special preparation is usually required, but following any instructions from your healthcare professional is important.

Reference range

Optimal: <100 mg/dLN/A

Specimen: serum

Fasting for 12-14 hours preferred. Water is permitted. Avoid alcohol for 24 hours before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

: LDL cholesterol

Frequently asked questions

: Does a high LDL cholesterol result mean I have heart disease?
: No. A high result indicates an increased risk of cardiovascular disease, but it does not by itself prove that heart disease is present. Imaging or other clinical evaluation may be needed for diagnosis.
: Can LDL cholesterol be lowered?
: Yes. Depending on your overall risk, your clinician may recommend dietary changes, regular physical activity, weight management, smoking cessation, or cholesterol-lowering medication.
: Is fasting required for this test?
: Fasting is not always required, but you may be asked to fast if the test is being performed as part of a complete lipid panel or if your healthcare professional requests it.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy