Low-Density Lipoprotein Cholesterol (LDL-C) from Serum

Why It’s Done

Doctors may order an LDL cholesterol test to assess your risk of heart disease, stroke, or other cardiovascular conditions. It’s often part of a broader lipid panel that also checks HDL cholesterol and total cholesterol. Your doctor may recommend this test if you have a family history of high cholesterol, high blood pressure, diabetes, or if you’re at higher risk for heart problems.

What to Expect

A blood sample is taken from a vein, usually in your arm. You may feel a slight pinch, but it’s quick. The test involves collecting serum (the liquid part of blood after clotting), which is then analyzed to measure LDL cholesterol levels.

How Results Are Used

Your LDL cholesterol result helps your doctor determine if your cholesterol levels are healthy or if lifestyle changes or medications (like statins) are needed to lower them. While LDL cholesterol is often called the 'bad' cholesterol, it’s not the only factor—your overall lipid profile and other health factors also play a role.

Preparation

No special preparation is usually needed, but you may be asked to fast for 9–12 hours before the test if it’s part of a fasting lipid panel. If you’re pregnant, have an infection, or are on certain medications, let your doctor know before testing.