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Levodopa/Creatinine Ratio, Urine

Published: August 9, 2026Updated: August 16, 2026

Measures the amount of levodopa in urine relative to creatinine, which can help assess how much levodopa the body is excreting.

Quick summary

["This urine test helps evaluate levodopa excretion, which may be affected by medication use, absorption, and kidney function."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
79577-3
Short code
L-Dopa/Creat Ur-sRto
Synonyms
L-Dopa/Creat Ur-sRto
Category
kidney
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What is this test?

This test measures levodopa, a medicine used to treat Parkinson's disease, in urine. The result is compared with the amount of creatinine in the same sample because creatinine helps account for differences in urine concentration.

Why might I need this test?

A clinician may order this test to evaluate how much levodopa is being absorbed and excreted. It may be used when medication effectiveness or side effects are concerns, particularly when results need to be interpreted alongside kidney function and medication timing.

How is the test performed?

A urine specimen is collected and tested to determine the levodopa and creatinine amounts. The laboratory then calculates the levodopa-to-creatinine ratio. Your clinician may request a single urine sample or a timed collection, depending on the purpose of the test.

How do I prepare for the test?

Follow your clinician's instructions about when and how to collect the urine. If a timed or 24-hour collection is requested, collect all urine during the specified period and record the start and end times. Take levodopa and other medicines as prescribed, and tell the laboratory about medications taken near the collection time.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

A higher or lower levodopa-to-creatinine ratio may reflect changes in levodopa dosing, absorption, metabolism, kidney function, or urine collection. The result is interpreted with other clinical findings and should not be used alone to adjust medication.

Short name

Urine Levodopa/Creatinine Ratio

Frequently asked questions

What does the urine levodopa-to-creatinine ratio show?
It shows the amount of levodopa excreted in urine relative to creatinine, which helps account for urine concentration. It can provide information about medication absorption and elimination.
Does this test show how well my Parkinson's medication is working?
It can provide useful information about levodopa handling, but it does not by itself measure symptom control or disease progression. Your clinician will interpret it with your symptoms, medication schedule, and other tests.
Do I need to collect all of my urine for this test?
That depends on the instructions from your clinician. Some tests use a single urine sample, while others require a timed or 24-hour collection. Follow the collection instructions provided with the test order.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy