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Total Protein in Serum or Plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood, which includes albumin and other proteins like globulins.

Quick summary

["Total protein helps assess your body’s protein balance and potential kidney or liver issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
23890-7
Short code
Lead Spec-mCnt
Synonyms
Lead Spec-mCnt
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to check for conditions like kidney disease, liver problems, malnutrition, or dehydration. It can also help monitor certain treatments or diagnose symptoms such as swelling, rapid weight loss, or fatigue.

What Does the Result Mean?

Results may be lower in cases of malnutrition, severe liver disease, or kidney problems, while elevated levels could suggest dehydration, multiple myeloma, or inflammatory conditions. Interpretation depends on your overall health and other test results.

Common Conditions Affecting Results

Low protein levels might indicate poor nutrient absorption, chronic illness, or excessive fluid loss. High levels could signal dehydration or certain cancers. Always discuss your results with your provider.

What to Expect Before the Test

No special preparation is needed, but you may fast if instructed. Bring any medications or questions to your appointment.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein

Frequently asked questions

How often will I need this test?
Frequency depends on your health status. Your provider will determine how often to check based on your symptoms, medical history, and other tests.
Can diet affect my protein test results?
Dietary changes may influence protein levels, so avoid high-protein foods 24 hours before testing if instructed. Stick to your usual diet unless advised otherwise.
What if my test results are out of range?
Your provider will discuss any abnormal results with you. They may recommend further tests or adjustments to your treatment plan based on the findings.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy