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Lead in Tissue (24-Hour Integrated)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of lead stored in your body tissues over a 24-hour period, helping assess long-term exposure.

Quick summary

["Long-term lead exposure can be tracked by checking stored lead levels in your body."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
52890-1
Short code
Lead Tiss-sCnt
Synonyms
Lead Tiss-sCnt
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Lead is a toxic metal that can accumulate in your body over time, especially in children and pregnant individuals. This test helps identify chronic exposure that standard urine or blood tests might miss. Lead can interfere with brain development, cause developmental delays, and increase risks for heart and kidney problems. Early detection is key to preventing harm.

What to Expect Before the Test

No special preparation is needed for this test. You’ll have a small sample of tissue (usually from a biopsy) analyzed for lead content. This is typically done under local anesthesia and is generally safe. Follow-up instructions from your healthcare provider will guide you on any dietary or activity restrictions post-procedure.

What the Results Mean

Results show the average lead concentration in your tissues over 24 hours. Higher levels may indicate ongoing exposure or poor elimination. Your doctor will interpret results in the context of your medical history, symptoms, and other tests. Elevated levels may prompt further investigation or treatment recommendations.

Common Causes of Elevated Lead Levels

Chronic exposure can come from contaminated food/water, dust, or environmental sources like old paint or pipes. Occupational exposure (e.g., battery manufacturing) or living in areas with high lead pollution may also contribute. Children are more vulnerable due to higher absorption rates and developing systems.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

24-Hour Lead Tissue Content

Frequently asked questions

How is this test different from a urine lead test?
Unlike urine tests, which measure lead excretion over a short period (e.g., 24 hours), this test reflects lead stored in your tissues over time. It provides a more comprehensive picture of long-term exposure, which can be critical for identifying chronic or persistent lead exposure that may not show up in acute urine tests.
Can lead levels be lowered without treatment?
Yes, reducing exposure to lead sources (e.g., removing contaminated items, improving ventilation) can help lower lead levels naturally. Dietary changes (e.g., increasing calcium, iron, and vitamin D) and avoiding lead-containing products may also support elimination. However, severe cases may require medical treatment like chelation therapy.
Is this test painful or risky?
The procedure involves a small tissue sample (e.g., from a biopsy) under local anesthesia, so it’s generally not painful. Risks are minimal, but any biopsy carries a slight risk of infection or bleeding. Follow your doctor’s post-procedure care instructions to minimize these risks.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy