Lipoprotein(a) [Lp(a)] concentration

What Is Lipoprotein(a)?

Lipoprotein(a) is a lipoprotein particle that combines cholesterol with a distinct protein called apolipoprotein(a). Unlike other cholesterol types, Lp(a) is genetically determined and does not change with diet or exercise. It may contribute to plaque buildup in arteries, increasing the risk of heart attacks or strokes.

Why Might You Need This Test?

Your healthcare provider may order this test if you have a family history of early heart disease, certain genetic conditions, or if you have high cholesterol that doesn’t improve with lifestyle changes. It’s also used in some risk assessments for people with conditions like aortic stenosis or peripheral artery disease.

How Is the Test Performed?

A blood sample is drawn from a vein, usually in your arm. The sample is sent to a lab where it’s analyzed using a specialized immunoassay method to measure Lp(a) levels.

What Do Results Mean?

Higher-than-normal Lp(a) levels may indicate an increased risk of cardiovascular problems, but results alone don’t diagnose a condition. They’re often used alongside other tests and risk factors to guide treatment or monitoring plans.